Naphthazarin Derivatives(VI)
...ophilicity of 6- acylDMNQderivatives For this purpose we synthesized more polar derivatives, oximes to cellular merabolism propted us to interoduce a propyl group, as a metabolsm retarding group in the structure of the oximese, so that the delayed metabolism may contribute to enhanedment of the antiproliferative activity. The inhibitory effect of the quinone derivatives on DNA topoisonerase-I(TOPO-I) was examined. 2-Acyl-1,4,9,10-terramethoxynaphthalene (TMN,1,4,9,10-tetramethoxynaphthalene)derivatives were treated with hydroxylamine to produce 2-(1-hydroxyiminoakyl)-TMI derivatives The oxime groupo of 2-(1hydroxyakly1)-TMNderivatives. The oxime group of 20(1-hydroxyimionalkyl)-TMN derivaties was propylated tto ro give 2-(1-propyloxyimionalkyl)-TMN derivatives. Next, both TMN derivatives were oxidized with chromium trioxide;the oxidation of 2-(10thydrominoalkyl)-TMN derivatives produed a miture 2- 6-(1hyftoxyminoakyl)TMN deriverves gave only 6-(1-propyloxyminoalkyl)-DNMNQ derivaties. the predominance of 6-isomers over CAN oxidation. However, the use of CAN led ro the vddddddTMN deriddddvatieves might be a cause of the exclusive production of 6-(1-propyloximinoalkyl)- DMNQ deriverageives in the oxidation. ddd dkid kid idBY SUBMITTING DATA OR MATERIALS TO GET FREE ESSAYS.COM, YOU PROMISE TO US THAT ANY DATA OR MATERIALS THAT YOU SUBMIT TO GET ...