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Irene Mungo
Bio 201
Alternative Assignment
05/19/03
The effects of an enriched environment on the expression of genes in the brain. ... Oligonucleotide microarrays were used to analyze gene expression in the brain. Many of the genes whose expression changed in an enriched environment were genes that are linked to the structure of neurons, synaptic plasticity and transmission of signals in the brain. ... Experiments carried out to examine the behavioral consequences of exposing rats to enriched environments were shown to induce biochemical and structural changes in the cortex and other brain regions. ...
To further demonstrate the effects of environmental enrichment in the brain, gene expression changes were analyzed in the cortex of mice after exposure to enriched environments for 3 hours to 14 days. ... Calmodulin, which among other things regulates clustering of neurotransmitter receptors at central synapses, was up-regulated after long-term enrichment. ... Many of these genes are involved in the structure of neurons, synaptic signaling, and plasticity in the brain regions.
Approximate Word count = 837
Approximate Pages = 3.3
(250 words per page double spaced)
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