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Schizophrenia • Was called Dementia Praecox (early dementia) • Then called schizophrenia (split mind) – Fragmentation of thought processes – Split between thought & emotions – Withdrawal from reality – NOT MPD • Affects 1% - 1 1/2% of population • Affects men & women about equally • More frequently seen in lower socioeconomic classes • More frequently seen in large cities vs. rural • More frequent in divorced/separated • 10-15% may commit suicide • Among the most severe disorders • Much heterogeneity in symptoms Symptoms of Schizophrenia • Positive Symptoms – Pathological additions to normal behavior • Negative Symptoms – Characteristics that are lacking or reduced • Psychomotor Symptoms – Odd gestures – Excited movement – Motionless stupor Positive Symptoms • Delusions - beliefs contrary to reality – Delusions of persecution • others are out to get you, victimize you, slander you – Delusions of reference • attach special and personal meaning to things that happen or to the behavior of others – Delusions of grandeur • believe oneself to have special importance or power – Delusions of control • belief that others are controlling your thoughts, feelings, or behavior • Disorganized Thinking or Speech – Loose associations • little apparent connection among thoughts – Conceptual difficulties • concrete thinking (i.e., difficulty thinking abstractly) – Peculiar word usage • Neologisms • Word Salad • Perseveration • Clang associations • Heightened Perceptions & Hallucinations – Sensory flooding • Difficulty distinguishing relevant from irrelevant sensory information – Hallucinations • perceptions contrary to reality • most often auditory • can be visual, tactile, somatic, gustatory, olfactory • Inappropriate Affect – Emotions unsuited to the situation • smile or laugh when describing something serious • sad or angry in some happy circumstance • inappropriate shifts in mood • inappropriately intense mood • may represent a response to another positive symptom (e.g., an hallucination) Negative Symptoms • Poverty of Speech – A decrease in speech or speech content (alogia) • little or no reply/meaning • Blunted or Flat Affect – blunted - less expression of feeling than most – flat - virtually no emotion – may reflect deficiency in experience of or expression of emotions • Loss of Volition – Avolition • feel drained of energy or interest in normal goals • unable to begin or follow through on activities – Ambivalence • Conflicted feelings about many things • Social Withdrawal – Social and emotional withdrawal from others Psychomotor Symptoms • Reduced spontaneous movement • Catatonia - extreme motor disturbance – Catatonic stupor • totally unresponsive (apparently unaware) • remain motionless/speechless for extended time – Catatonic rigidity & posturing • remain rigid & upright for hours • resist efforts to be moved • may assume awkward posture • waxy flexibility – Catatonic Excitement • extreme/uncontrolled hyperactivity Types of Schizophrenia • Catatonic Schizophrenia – Psychomotor Disturbance • immobility • excessive motor activity • extreme negativism • posturing • repetition of speech or sounds Paranoid Schizophrenia – Preoccupation with one or more delusions or frequent hallucinations (auditory) – Absence of other schizophrenic symptoms • Disorganized Schizophrenia – Severe disintegration of personality – Incoherent/disorganized speech or behavior – Flat or inappropriate affect • Undifferentiated Schizophrenia – Meets criteria for schizophrenia, but not for any of the above sub-categories • Residual Schizophrenia – Been schizophrenic – No longer active symptoms of schizophrenia – Continuing evidence of symptoms Etiology of Schizophrenia • Biological Factors – Runs in families – Strong genetic component – Brain Anomalies • enlarged ventricles • reduced size of some areas – Biochemical Abnormalities • Neurotransmitters – Dopamine » relationship to Parkinson’s Disease/L-Dopa » maybe too many D-2 Dopamine Receptors » especially in Type I • Serotonin – especially in Type II – Infectious Agents • e.g., pre-natal exposure to influenza • related to birth month • pattern similar to stillbirths Psychosocial Factors • Family Dysfunction – Schizophrenogenic mother • cold and domineering • little empirical support – Disturbed Family Communication • Vague, unclear, disorganized communication – Mixed support – Cause/Effect not clear • Expressed Emotion – Family members express critical or overprotective emotions – Predictive of relapse Diathesis - Stress Model • Concordance rate is never more than 50% • More than genetics involved • Combination of physiological vulnerability and life stresses may be needed • Physiological vulnerability may be non-genetic – Birth complications or in-utero viral exposure • Combination may be different for different schizophrenic presentations – Positive vs.


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