aetiology of Alzheimer s is unknown but many different explanations have been proposed Identify and critically
The aetiology of Alzheimer’s is unknown but many different explanations have been proposed. Identify and critically evaluate some of the leading explanations. Much progress has occurred in the epidemiology of Alzheimer’s disease. ... Alzheimer’s is considered to be a ‘degenerative disease’ that effects ‘memory, thinking and behaviour’ Goate et Ashall (1995) Blocq et Marinesco (1892) was the first to discover Alzheimer disease microscopically however the classification of Alzheimer’s disease still remains unanswered as many consider it to be a neurodegenerative disorder however many believe it to be a vascular disorder De La Torre (2002) as the Rotterdam study attempted to prove Hofman et al (1997). Alzheimer’s is often not diagnosed as it is often confused with senility and senescence De La Torre et al (2002) as many symptoms reflect this. Only the primary explanations for the aetiology of Alzheimer’s disease will be discussed here such as Plaques and Tangles Braak et Braak (1991), Genetic causes Tanzi et al (1987) and also ageing Chen et Fernandez (2000). It will also be proposed that both environmental and genetic factors will be included Davies (1989) and investigated as the aetiology is still unknown however many significant risk factors have been proposed. Other less known aetiologies for Alzheimer’s will be exempt such as hypertension and hi serum viscosity De La Torre (2000) as they are not leading explanations for the aetiology of Alzheimer’s. Risk factors will be considered on singular merit however the multifactor nature of Alzheimer should also be considered Becaria (2003) as many risk factors could combine together for the aetiology of Alzheimer’s. Other aetiologies must be investigated as Nishimura (1996) stated as only fifty to sixty per cent of people can be explained with genetic aetiology so other aetiologies must be investigated. Alzheimer’s disease affects the neurons and the synapses within the brain Biggs et al (1989). The processes that occur within Alzheimer disease segregates, affects communication and reproduction of neurons within the brain. ... All or some of these features may be present in Alzheimer’s DSM IV (2000) and one of the leading explanations is senile plaques and diffuses plaques abnormalities in the brain. ... Beta amyloid is toxic to neurons and may destroy them and could possibly contribute to Alzheimer’s disease Levy et al (1995). ... And can explain why staining and fixation can be carried out Goate et Ashall (1995) This death of cells may contribute to Alzheimer’s disease although Plaques and Tangles are often seen togther Braak et Braak (1991).