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... Here we demonstrated that expression of BA46, like MUC1, is not restricted to breast cancer as was reported (37), but it is also expressed by other adenocarcinomas like colon, bladder and ovarian tumor cells. ... MDA-MB-231 was a better candidate than MCF7, because the tumors did not regress spontaneously and grew in 100% of cases compare to usual 70% of tumor growth in mice inoculated with MCF7 cells. ... To our intuition, single adoptive transfer of tumor specific CTLs is not enough, because theoretically the activated CTLs cannot stay viable for a long time (more than month in our case). To this extend, a number of transfers is essential to mimic the real situation in the body, when the extended clone of CTL is not disappear, because the naïve cytotoxic T cells with the same specificity still exist. ... Indeed, the specific lysis peptide pulsed target cells by peptide stimulated PBLs derived from breast cancer patients, but not by those derived from healthy individuals, supports the hypothesis that the peripheral blood of these patients but not in the blood healthy individual contains primed CTLs capable of recognizing MUC1- and BA46-derived peptides.
Approximate Word count = 802
Approximate Pages = 3.2
(250 words per page double spaced)
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