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Spread of pigment from the edge of the mole into the skin that used to be normal looking Finding redness or swelling (inflammation) A very late sign is the development of satellite pigmentation (that is, nodules of pigmentation next to, but not a direct part of a mole) Onset of new feelings or symptoms in a mole - itchy, tender, painful, scaling Bleeding 3. Etiology / Carcinogens / Risks Originates in pigment producing cells (melanocytes) A person who has developed one melanoma has increased chance of developing more Patients who have been successfully treated must be monitored carefully Melanomas are most common in light-skinned people with freckles, and many moles In white women melanomas occur most often on the back and lower limbs; in white men on the trunk Exposure to sunshine increases the risk, particularly repeated or intermittent episodes of intense sun exposure in childhood Melanoma is most common in people in their forties to sixties Melanoma is rare before puberty Some moles called dysplastic nevi (atypical nevi), are more likely to become melanomas than others. Dysplastic nevi often appear larger than normal nevi (more than 5 mm across), often with irregularity of edge and variable color. Even though large in diameter, they are often quite flat Certain families are prone to develop dysplastic nevi and once a family member is identified as having one such nevus, other family members should have their moles examined by their doctor.