synthesis and characterization of transition metal compounds
...n the Figure 1.1. Azomycin, a derivative of imidazole occurs in nature. However, direct synthesis using HNO3 and H2SO4 is virtually impossible. The derivative 4(5)-nitroimidazole can easily be prepared in the laboratory but under harsh conditions. Nitrated aromatic heterocycles are important compounds for many reasons. Many important anti-malarial, anti-protozoal, and anti-cancer agents are nitrated heterocycles. The study of imidazole and its derivatives has been a prominent study for inorganic chemists within the past decade. In 1983, Storm and his coworkers studied the pKa of complexes that were coordinated to an inert metal. His study reported that when a metal was coordinated to a complex, the pKa was approximately four times greater in pKa units than the unbound molecule with a pKa of approximately 4 in pKa units.1 The figure below supports Storm’s findings. In 1984, Brodsky and his coworkers studied the introduction of a nitro group by electrophilic substitution. Storm’s research related to that of Brodsky’s research in that with the ring being more basic, the introduction of a nitro group onto the ring is much more favorable. The study of this research focused on the det...