Lysogenic review
...the early thirties a definition of lysogeny was reached that are still valid, using the concept of prophage by Burnet and McKie. In the early of 1949, Giuseppe Bertani, the author of the article, first encountered lysogeny during one of his experiments. At about the same time, two important events happened. One, in Madision, Estther and Joshua Lederberg with their experiment conclude that the original K-12 strain of E. coli was lysogenic for previously unexpected phage, which was name lambda. Two, in Paris, Andre Lwoff, with his study with oversized Bacillus megaterim, found out that bacteria could grow and divide several times without producing any phage. In the early of 1950, Bertanie with the help of Salvador Luria first studied the lambda strain. The study however was interrupted due to the request of Luria. Without giving up, using the Lisbonne (Li) strain and Shigella, Bertani set out to investigate essentially the same problem as Lwoff. It was confirmed that phage production by a lysogen was discontinuous, involving rare, large burst of phage. Further investigation showed that strain Li did indeed produce three immunologically distinct types of phages, which were named P1, P2, and P3. Outside of lysogeny, P1 and P2 also contributed more generally to the early progress in bacterial genetics. One of the examples includes the discovery of “host-controlled variatio...